TY - JOUR AU - Massague, J. PY - 2004 DA - 2004// TI - G1 cell-cycle control and cancer JO - Nature VL - 432 UR - https://doi.org/10.1038/nature03094 DO - 10.1038/nature03094 ID - Massague2004 ER - TY - JOUR AU - Sherr, C. AU - Roberts, J. PY - 1999 DA - 1999// TI - CDK inhibitors: positive and negative regulators of G1-phase progression JO - Genes Dev VL - 13 UR - https://doi.org/10.1101/gad.13.12.1501 DO - 10.1101/gad.13.12.1501 ID - Sherr1999 ER - TY - JOUR AU - Russo, A. AU - Jeffrey, P. AU - Patten, A. AU - Massague, J. AU - Pavletich, N. PY - 1996 DA - 1996// TI - Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex JO - Nature VL - 382 UR - https://doi.org/10.1038/382325a0 DO - 10.1038/382325a0 ID - Russo1996 ER - TY - JOUR AU - Nho, R. AU - Sheaff, R. PY - 2003 DA - 2003// TI - p27kip1 contributions to cancer JO - Progress in Cell Cycle Research VL - 5 ID - Nho2003 ER - TY - JOUR AU - Kawamata, N. AU - Morosetti, R. AU - Miller, C. AU - Park, D. AU - Spirin, K. AU - Nakamaki, T. AU - Takeuchi, S. AU - Hatta, Y. AU - Simpson, J. AU - Wilcyznski, S. PY - 1995 DA - 1995// TI - Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies JO - Cancer Res VL - 55 ID - Kawamata1995 ER - TY - JOUR AU - Slingerland, J. AU - Pagano, M. PY - 2000 DA - 2000// TI - Regulation of the cdk inhibitor p27 and its deregulation in cancer JO - J Cell Physiol VL - 183 UR - https://doi.org/3.0.CO;2-I DO - 3.0.CO;2-I ID - Slingerland2000 ER - TY - JOUR AU - Ponce-Castaneda, M. AU - Lee, M. AU - Latres, E. AU - Polyak, K. AU - Lacombe, L. AU - Montgomery, K. AU - Mathew, S. AU - Krauter, K. AU - Sheinfeld, J. AU - Massague, J. PY - 1995 DA - 1995// TI - p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors JO - Cancer Res VL - 55 ID - Ponce-Castaneda1995 ER - TY - JOUR AU - Nakayama, K. AU - Ishida, N. AU - Shirane, M. AU - Inomata, A. AU - Inoue, T. AU - Shishido, N. AU - Horii, I. AU - Loh, D. Y. AU - Nakayama, K. PY - 1996 DA - 1996// TI - Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors JO - Cell VL - 85 UR - https://doi.org/10.1016/S0092-8674(00)81237-4 DO - 10.1016/S0092-8674(00)81237-4 ID - Nakayama1996 ER - TY - JOUR AU - Kiyokawa, H. AU - Kineman, R. AU - Manova-Todorova, K. AU - Soares, V. AU - Hoffman, E. AU - Ono, M. AU - Khanam, D. AU - Hayday, A. AU - Frohman, L. AU - Koff, A. PY - 1996 DA - 1996// TI - Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1) JO - Cell VL - 85 UR - https://doi.org/10.1016/S0092-8674(00)81238-6 DO - 10.1016/S0092-8674(00)81238-6 ID - Kiyokawa1996 ER - TY - JOUR AU - Fero, M. AU - Rivkin, M. AU - Tasch, M. AU - Porter, P. AU - Carow, C. AU - Firpo, E. AU - Polyak, K. AU - Tsai, L. AU - Broudy, V. AU - Perlmutter, R. AU - Kaushansky, K. AU - Roberts, J. PY - 1996 DA - 1996// TI - A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice JO - Cell VL - 85 UR - https://doi.org/10.1016/S0092-8674(00)81239-8 DO - 10.1016/S0092-8674(00)81239-8 ID - Fero1996 ER - TY - JOUR AU - Philipp-Staheli, J. AU - Payne, S. AU - Kemp, C. PY - 2001 DA - 2001// TI - p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer JO - Exp Cell Res VL - 264 UR - https://doi.org/10.1006/excr.2000.5143 DO - 10.1006/excr.2000.5143 ID - Philipp-Staheli2001 ER - TY - JOUR AU - Fero, M. AU - Randel, E. AU - Gurley, K. AU - Roberts, J. AU - Kemp, C. PY - 1998 DA - 1998// TI - The murine gene p27Kip1 is haplo-insufficient for tumour suppression JO - Nature VL - 396 UR - https://doi.org/10.1038/24179 DO - 10.1038/24179 ID - Fero1998 ER - TY - JOUR AU - Koff, A. AU - Ohtsuki, M. AU - Polyak, K. AU - Roberts, J. AU - Massague, J. PY - 1993 DA - 1993// TI - Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta JO - Science VL - 260 UR - https://doi.org/10.1126/science.8475385 DO - 10.1126/science.8475385 ID - Koff1993 ER - TY - JOUR AU - Hengst, L. AU - Dulic, V. AU - Slingerland, J. AU - Lees, E. AU - Reed, S. PY - 1994 DA - 1994// TI - A cell cycle-regulated inhibitor of cyclin-dependent kinases JO - Proc Natl Acad Sci USA VL - 91 UR - https://doi.org/10.1073/pnas.91.12.5291 DO - 10.1073/pnas.91.12.5291 ID - Hengst1994 ER - TY - JOUR AU - Toyoshima, H. AU - Hunter, T. PY - 1994 DA - 1994// TI - p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21 JO - Cell VL - 78 UR - https://doi.org/10.1016/0092-8674(94)90573-8 DO - 10.1016/0092-8674(94)90573-8 ID - Toyoshima1994 ER - TY - JOUR AU - Slingerland, J. AU - Hengst, L. AU - Pan, C. AU - Alexander, D. AU - Stampfer, M. AU - Reed, S. PY - 1994 DA - 1994// TI - A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells JO - Mol Cell Biol VL - 14 UR - https://doi.org/10.1128/MCB.14.6.3683 DO - 10.1128/MCB.14.6.3683 ID - Slingerland1994 ER - TY - JOUR AU - Denicourt, C. AU - Dowdy, S. PY - 2004 DA - 2004// TI - Cip/Kip proteins: more than just CDKs inhibitors JO - Genes Dev VL - 18 UR - https://doi.org/10.1101/gad.1205304 DO - 10.1101/gad.1205304 ID - Denicourt2004 ER - TY - JOUR AU - Moeller, S. AU - Head, E. AU - Sheaff, R. PY - 2003 DA - 2003// TI - p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation JO - Mol Cell Biol VL - 23 UR - https://doi.org/10.1128/MCB.23.11.3735-3752.2003 DO - 10.1128/MCB.23.11.3735-3752.2003 ID - Moeller2003 ER - TY - JOUR AU - Besson, A. AU - Gurian-West, M. AU - Schmidt, A. AU - Hall, A. AU - Roberts, J. PY - 2004 DA - 2004// TI - p27Kip1 modulates cell migration through the regulation of RhoA activation JO - Genes Dev VL - 18 UR - https://doi.org/10.1101/gad.1185504 DO - 10.1101/gad.1185504 ID - Besson2004 ER - TY - JOUR AU - Sgambato, A. AU - Cittadini, A. AU - Faraglia, B. AU - Weinstein, I. PY - 2000 DA - 2000// TI - Multiple functions of p27(Kip1) and its alterations in tumor cells: a review JO - J Cell Physiol VL - 183 UR - https://doi.org/3.0.CO;2-S DO - 3.0.CO;2-S ID - Sgambato2000 ER - TY - JOUR AU - Tetsu, O. AU - McCormick, F. PY - 2003 DA - 2003// TI - Proliferation of cancer cells despite CDK2 inhibition JO - Cancer Cell VL - 3 UR - https://doi.org/10.1016/S1535-6108(03)00053-9 DO - 10.1016/S1535-6108(03)00053-9 ID - Tetsu2003 ER - TY - JOUR AU - Sugiyama, Y. AU - Tomoda, K. AU - Tanaka, T. AU - Arata, Y. AU - Yoneda-Kato, N. AU - Kato, J. PY - 2001 DA - 2001// TI - Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1 JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M010811200 DO - 10.1074/jbc.M010811200 ID - Sugiyama2001 ER - TY - JOUR AU - Zeng, Y. AU - Hirano, K. AU - Hirano, M. AU - Nishimura, J. AU - Kanaide, H. PY - 2000 DA - 2000// TI - Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor JO - Biochem Biophys Res Commun VL - 274 UR - https://doi.org/10.1006/bbrc.2000.3098 DO - 10.1006/bbrc.2000.3098 ID - Zeng2000 ER - TY - JOUR AU - Sheaff, R. AU - Groudine, M. AU - Gordon, M. AU - Roberts, J. AU - Clurman, B. PY - 1997 DA - 1997// TI - Cyclin E-CDK2 is a regulator of p27Kip1 JO - Genes Dev VL - 11 UR - https://doi.org/10.1101/gad.11.11.1464 DO - 10.1101/gad.11.11.1464 ID - Sheaff1997 ER - TY - JOUR AU - Tsvetkov, L. AU - Yeh, K. AU - Lee, S. AU - Sun, H. AU - Zhang, H. PY - 1999 DA - 1999// TI - p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 JO - Curr Biol VL - 9 UR - https://doi.org/10.1016/S0960-9822(99)80290-5 DO - 10.1016/S0960-9822(99)80290-5 ID - Tsvetkov1999 ER - TY - JOUR AU - Pagano, M. AU - Tam, S. AU - Theodoras, A. AU - Beer-Romero, P. AU - Del Sal, G. AU - Chau, V. AU - Yew, P. AU - Draetta, G. AU - Rolfe, M. PY - 1995 DA - 1995// TI - Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 JO - Science VL - 269 UR - https://doi.org/10.1126/science.7624798 DO - 10.1126/science.7624798 ID - Pagano1995 ER - TY - JOUR AU - Vlach, J. AU - Hennecke, S. AU - Amati, B. PY - 1997 DA - 1997// TI - Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27 JO - EMBO J VL - 16 UR - https://doi.org/10.1093/emboj/16.17.5334 DO - 10.1093/emboj/16.17.5334 ID - Vlach1997 ER - TY - JOUR AU - Ishida, N. AU - Kitagawa, M. AU - Hatakeyama, S. AU - Nakayama, K. PY - 2000 DA - 2000// TI - Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.M001144200 DO - 10.1074/jbc.M001144200 ID - Ishida2000 ER - TY - JOUR AU - Boehm, M. AU - Yoshimoto, T. AU - Crook, M. AU - Nallamshetty, S. AU - True, A. AU - Nabel, G. AU - Nabel, E. PY - 2002 DA - 2002// TI - A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression JO - EMBO J VL - 21 UR - https://doi.org/10.1093/emboj/cdf343 DO - 10.1093/emboj/cdf343 ID - Boehm2002 ER - TY - JOUR AU - Fujita, N. AU - Sato, S. AU - Katayama, K. AU - Tsuruo, T. PY - 2002 DA - 2002// TI - Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.C100762200 DO - 10.1074/jbc.C100762200 ID - Fujita2002 ER - TY - JOUR AU - Rodier, G. AU - Montagnoli, A. AU - Di Marcotullio, L. AU - Coulombe, P. AU - Draetta, G. AU - Pagano, M. AU - Meloche, S. PY - 2001 DA - 2001// TI - p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis JO - EMBO J VL - 20 UR - https://doi.org/10.1093/emboj/20.23.6672 DO - 10.1093/emboj/20.23.6672 ID - Rodier2001 ER - TY - JOUR AU - Ishida, N. AU - Hara, T. AU - Kamura, T. AU - Yoshida, M. AU - Nakayama, K. AU - Nakayama, K. PY - 2002 DA - 2002// TI - Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.C100762200 DO - 10.1074/jbc.C100762200 ID - Ishida2002 ER - TY - JOUR AU - Osaki, M. AU - Oshimura, M. AU - Ito, H. PY - 2004 DA - 2004// TI - PI3K-Akt pathway: its functions and alterations in human cancer JO - Apoptosis VL - 9 UR - https://doi.org/10.1023/B:APPT.0000045801.15585.dd DO - 10.1023/B:APPT.0000045801.15585.dd ID - Osaki2004 ER - TY - JOUR AU - Liang, J. AU - Slingerland, J. PY - 2003 DA - 2003// TI - Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression JO - Cell Cycle VL - 2 UR - https://doi.org/10.4161/cc.2.4.433 DO - 10.4161/cc.2.4.433 ID - Liang2003 ER - TY - JOUR AU - Vivanco, I. AU - Sawyers, C. PY - 2002 DA - 2002// TI - The phosphatidylinositol 3-Kinase AKT pathway in human cancer JO - Nat Rev Cancer VL - 2 UR - https://doi.org/10.1038/nrc839 DO - 10.1038/nrc839 ID - Vivanco2002 ER - TY - JOUR AU - Medema, R. AU - Kops, G. AU - Bos, J. AU - Burgering, B. PY - 2000 DA - 2000// TI - AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 JO - Nature VL - 404 UR - https://doi.org/10.1038/35008115 DO - 10.1038/35008115 ID - Medema2000 ER - TY - JOUR AU - Chakravarthy, M. AU - Abraha, T. AU - Schwartz, R. AU - Fiorotto, M. AU - Booth, F. PY - 2000 DA - 2000// TI - Insulin-like growth factor-I extends in vitro replicative life span of skeletal muscle satellite cells by enhancing G1/S cell cycle progression via the activation of phosphatidylinositol 3'-kinase/Akt signaling pathway JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.M005832200 DO - 10.1074/jbc.M005832200 ID - Chakravarthy2000 ER - TY - JOUR AU - Yakes, F. AU - Chinratanalab, W. AU - Ritter, C. AU - King, W. AU - Seelig, S. AU - Arteaga, C. PY - 2002 DA - 2002// TI - Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action JO - Cancer Res VL - 62 ID - Yakes2002 ER - TY - JOUR AU - Viglietto, G. AU - Motti, M. L. AU - Bruni, P. AU - Melillo, R. M. AU - D'Alessio, A. AU - Califano, D. AU - Vinci, F. AU - Chiappetta, G. AU - Tsichlis, P. AU - Bellacosa, A. AU - Fusco, A. AU - Santoro, M. PY - 2002 DA - 2002// TI - Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer JO - Nature Med VL - 8 UR - https://doi.org/10.1038/nm762 DO - 10.1038/nm762 ID - Viglietto2002 ER - TY - JOUR AU - Shin, I. AU - Yakes, F. AU - Rojo, F. AU - Shin, N. AU - Bakin, A. AU - Baselga, J. AU - Arteaga, C. PY - 2002 DA - 2002// TI - PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization JO - Nature Med VL - 8 UR - https://doi.org/10.1038/nm759 DO - 10.1038/nm759 ID - Shin2002 ER - TY - JOUR AU - Liang, J. AU - Zubovitz, J. AU - Petrocelli, T. AU - Kotchetkov, R. AU - Connor, M. AU - Han, K. AU - Lee, J. AU - Ciarallo, S. AU - Catzavelos, C. AU - Beniston, R. AU - Franssen, E. AU - Slingerland, J. PY - 2002 DA - 2002// TI - PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest JO - Nature Med VL - 8 UR - https://doi.org/10.1038/nm761 DO - 10.1038/nm761 ID - Liang2002 ER - TY - JOUR AU - Motti, M. AU - De Marco, C. AU - Califano, D. AU - Fusco, A. AU - Viglietto, G. PY - 2004 DA - 2004// TI - Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer JO - Cell Cycle VL - 3 UR - https://doi.org/10.4161/cc.3.8.1073 DO - 10.4161/cc.3.8.1073 ID - Motti2004 ER - TY - JOUR AU - Boyle, W. AU - van der Geer, P. AU - Hunter, T. PY - 1991 DA - 1991// TI - Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates JO - Methods Enzymol VL - 201 UR - https://doi.org/10.1016/0076-6879(91)01013-R DO - 10.1016/0076-6879(91)01013-R ID - Boyle1991 ER - TY - JOUR AU - Cardone, M. AU - Roy, N. AU - Stennicke, H. AU - Salvesen, G. AU - Franke, T. AU - Stanbridge, E. AU - Frisch, S. AU - Reed, J. PY - 1998 DA - 1998// TI - Regulation of cell death protease caspase-9 by phosphorylation JO - Science VL - 282 UR - https://doi.org/10.1126/science.282.5392.1318 DO - 10.1126/science.282.5392.1318 ID - Cardone1998 ER - TY - JOUR AU - Fujita, E. AU - Jinbo, A. AU - Matuzaki, H. AU - Konishi, H. AU - Kikkawa, U. AU - Momoi, T. PY - 1999 DA - 1999// TI - Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9 JO - Biochem Biophys Res Commun VL - 264 UR - https://doi.org/10.1006/bbrc.1999.1387 DO - 10.1006/bbrc.1999.1387 ID - Fujita1999 ER - TY - JOUR AU - Alessi, D. AU - Caudwell, F. B. AU - Andjelkovic, M. AU - Hemmings, B. A. AU - Cohen, P. PY - 1996 DA - 1996// TI - Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase JO - FEBS Letters VL - 399 UR - https://doi.org/10.1016/S0014-5793(96)01370-1 DO - 10.1016/S0014-5793(96)01370-1 ID - Alessi1996 ER - TY - JOUR AU - Zhou, B. AU - Liao, Y. AU - Xia, W. AU - Spohn, B. AU - Lee, M. AU - Hung, M. PY - 2001 DA - 2001// TI - Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells JO - Nat Cell Biol VL - 3 UR - https://doi.org/10.1038/35060032 DO - 10.1038/35060032 ID - Zhou2001 ER - TY - JOUR AU - Li, Y. AU - Dowbenko, D. AU - Lasky, L. PY - 2002 DA - 2002// TI - AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M109062200 DO - 10.1074/jbc.M109062200 ID - Li2002 ER - TY - JOUR AU - Meier, R. AU - Alessi, D. AU - Cron, P. AU - Andjelkovic, M. AU - Hemmings, B. PY - 1997 DA - 1997// TI - Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta JO - J Biol Chem VL - 272 UR - https://doi.org/10.1074/jbc.272.48.30491 DO - 10.1074/jbc.272.48.30491 ID - Meier1997 ER - TY - JOUR AU - Ostrakhovitch, E. A. AU - Lordnejad, M. R. AU - Schliess, F. AU - Sies, H. AU - Klotz, L. O. PY - 2002 DA - 2002// TI - Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species JO - Arch Biochem Biophys VL - 397 UR - https://doi.org/10.1006/abbi.2001.2559 DO - 10.1006/abbi.2001.2559 ID - Ostrakhovitch2002 ER - TY - JOUR AU - Shaw, M. AU - Cohen, P. AU - Alessi, D. R. PY - 1998 DA - 1998// TI - The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2 JO - Biochem J VL - 336 UR - https://doi.org/10.1042/bj3360241 DO - 10.1042/bj3360241 ID - Shaw1998 ER - TY - JOUR AU - Esposito, F. AU - Chirico, G. AU - Montesano Gesualdi, N. AU - Posadas, I. AU - Ammendola, R. AU - Russo, T. AU - Cirino, G. AU - Cimino, F. PY - 2003 DA - 2003// TI - Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires SRC activity JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M211841200 DO - 10.1074/jbc.M211841200 ID - Esposito2003 ER - TY - JOUR AU - Wang, X. AU - McCullough, K. D. AU - Franke, T. F. AU - Holbrook, N. J. PY - 2000 DA - 2000// TI - Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.275.19.14624 DO - 10.1074/jbc.275.19.14624 ID - Wang2000 ER -