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Figure 1 | Cell Division

Figure 1

From: The cyclin D1b splice variant: an old oncogene learns new tricks

Figure 1

The cyclin D1 transcript is subject to alternative splicing. Alternative splicing is known to occur at the exon4/intron 4 boundary. Effective splicing at this junction results in the well-characterized cyclin D1 product (bottom left), which contains discrete motifs that regulate cell cycle control, subcellular localization, and transcriptional regulation. Failure to splice at the exon4/intron 4 boundary results in the cyclin D1b protein product, which harbors a divergent C-terminus (hatched region). The G/A870 polymorphism (circled) is thought to influence the splicing event.

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