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Figure 3 | Cell Division

Figure 3

From: Paradoxical expression of INK4c in proliferative multiple myeloma tumors: bi-allelic deletion vs increased expression

Figure 3

Effect of increased proliferation or increased p18INK4c expression on survival of multiple myeloma patients. Survival data and Affymetrix U133_2.0_Plus RNA expression data was obtained for 596 individuals with MM, including 559 newly diagnosed patients and 37 patients in relapse. Kaplan-Meier curves of overall survival are shown. Compared to the total population, 101 patients with an expression- based proliferation index (PI) >2 had a significantly shorter survival (P < 0.0001), and 107 patients with a normalized p18INK4c expression > 2 also had a significantly shorter survival (P = 0.0005).

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