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Table 1 Examples of F-box proteins that function independently of Skp1

From: F-box proteins: more than baits for the SCF?

F-box protein Organism Reference Function
Rca1 D. melanogaster 25–28 Inhibition of Anaphase Promoting Complex in G2
Mfb1 S. cerevisiae 30, 31 Mitochondrial distribution and morphology
Mdm30 S. cerevisiae 30, 31 Mitochondrial distribution and morphology
Fbh1* H. sapiens, S. pombe 33–36 Repression of recombination (DNA helicase)
MoKA M. musculus 37 Transcription factor co-activator
Pof14 S. pombe 38 Repression of ergosterol synthesis
  1. *in this case, it is unclear if the F-box is required in vivo. Note that some of the F-box proteins cited bind Skp1 or form an SCF complex but the function indicated is independent of this binding. Species included are Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster, Homo sapiens and Mus musculus.