F-box proteins: more than baits for the SCF?

Cell Division

Table 1 Examples of F-box proteins that function independently of Skp1

F-box protein	Organism	Reference	Function
Rca1	D. melanogaster	25–28	Inhibition of Anaphase Promoting Complex in G2
Mfb1	S. cerevisiae	30, 31	Mitochondrial distribution and morphology
Mdm30	S. cerevisiae	30, 31	Mitochondrial distribution and morphology
Fbh1*	H. sapiens, S. pombe	33–36	Repression of recombination (DNA helicase)
MoKA	M. musculus	37	Transcription factor co-activator
Pof14	S. pombe	38	Repression of ergosterol synthesis

*in this case, it is unclear if the F-box is required in vivo. Note that some of the F-box proteins cited bind Skp1 or form an SCF complex but the function indicated is independent of this binding. Species included are Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster, Homo sapiens and Mus musculus.

ISSN: 1747-1028