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Table 1 CDKs and regulatory proteins encoded by the C. elegans genome

From: Cyclin-dependent kinases in C. elegans

Protein

C. elegans homolog

Function

 

Protein name

Cosmid name

 

CDKs

CDK1

CDK-1

T05G5.3

Entry into mitosis(e) [25]

CDK2

-

K03E5.3

S phase entry/progression(p)

CDK4/CDK6

CDK-4

F18H3.5

G1/S progression(e) [64, 100]

CDK5

CDK-5

T27E9.3

Neuronal development/functioning(p)

CDK7

CDK-7

Y39G10AL.3

CDK activating kinase, RNA pol II phosphorylation(e) [81]

CDK8

CDK-8

F39H11.3

Transcriptional regulation(p)

CDK9

CDK-9

H25P06.2

RNA pol II phosphorylation(e) [82]

Cyclins

Cyclin A

CYA-1

ZK507.6

CDK-1/CDK-2 partner(p)

 

CYA-2

F59H6.7

CDK-1/CDK-2 partner(p)

Cyclin B

CYB-1

ZC168.4

CDK-1 partner(e) [31]

 

CYB-2.1

Y43E12A.1

CDK-1 partner(p)

 

CYB-2.2

H31G24.4

CDK-1 partner(p)

Cyclin B3

CYB-3

T06E6.2

CDK-1 partner(e) [31]

Cyclin C

CIC-1

H14E04.5

CDK-8 partner(p)

Cyclin D

CYD-1

Y38F1A.5

CDK-4 partner(e) [64]

Cyclin E

CYE-1

C37A2.4

CDK-2 partner(p)

Cyclin H

CYH-1

Y49F6B.1

CDK-7 partner(p)

Cyclin T

CIT-1.1

F44B9.4

CDK-9 partner(p)

 

CIT-1.2

F44B9.3

CDK-9 partner(p)

p35

CDKA-1

T23F11.3

CDK-5 activating subunit(p)

Other

Cip/Kip

CKI-1

T05A6.1

Negative regulator of G1 progression, likely through inhibition of CDK-2(e) [70]

 

CKI-2

T05A6.2

Unknown

Wee1/Myt1

WEE-1.1

F35H8.7

Negative regulator of CDK-1(p)

 

WEE-1.3

Y53C12A.1

Negative regulation of meiotic progression, likely through CDK-1 phosphorylation(e) [32]

Cdc25

CDC-25.1

K06A5.7

Dephosphorylation of inhibitory CDK residues(p)

 

CDC-25.2

F16B4.8

Dephosphorylation of inhibitory CDK residues(p)

 

CDC-25.3

ZK637.11

Dephosphorylation of inhibitory CDK residues(p)

 

CDC-25.4

R05H5.2

Dephosphorylation of inhibitory CDK residues(p)

CKS1

DOM-6

C09G4.3

Required for exit from meiosis and mitosis(e) [97]

  1. C. elegans homologs of mammalian CDKs for with established functions, their predicted cyclin partners, and several key regulators of CDK activity.
  2. (e) function experimentally determined in C. elegans
  3. (p) function predicted based on homologs in other organisms