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Figure 2 | Cell Division

Figure 2

From: Restriction beyond the restriction point: mitogen requirement for G2 passage

Figure 2

Extending the restriction point. A. Cell cycle progression is dependent on CYCLIN-CDK kinase activity. B. Mitogen starvation results in cell cycle arrest in G1 through degradation or suppression of CYCLIN D and CKI-mediated inhibition of CYCLIN E-CDK2. C. Unscheduled passage through the G1 restriction point in the absence of mitogens (e.g., through RB loss) results in cell cycle arrest in G2.

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