Figure 2
From: Resolving RAD51C function in late stages of homologous recombination
A late role for RAD51C in meiotic recombination. RAD51C's late role in meiotic recombination is revealed in oocytes that were allowed to progress to metaphase II in vivo following hormonal treatment. A. At metaphase II, oocytes from control females show the presence of 20 pairs of chromatids, each consisting of two sister chromatids that are attached at their centromeres. B. Oocytes from infertile Rad51c mutant mice display a variety of chromosomal abnormalities. The majority of the mutant oocytes show precocious separation of sister chromatids. Inset in "D" is a higher magnification of the group of chromosomes showing an acentric chromatid (arrowhead) and a chromatid with two centromeres (double arrow). (Reproduced from The Journal of Cell Biology, 2007, 176:581–592, Copyright 2007, The Rockefeller University Press.)