Figure 1From: The role of CDK in the initiation step of DNA replication in eukaryotesA model for CDK-regulated initiation of chromosome DNA replication. Pre-replicative complexes are formed at origins of DNA replication in G1 (top). When S-CDK is activated, it phosphorylates Sld2 and Sld3. These phosphorylations promote complex formation between Sld2 and Sld3 and Dpb11. This reaction triggers the initiation of DNA replication.Back to article page