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Table 1 Dpb11 orthologues

From: The role of CDK in the initiation step of DNA replication in eukaryotes

Species Gene product Features
S. cerevisiae Dpb11 4x BRCT. N-terminal and C-terminal pair binds phosphorylated Sld3 and phosphorylated Sld2, respectively. [6, 12, 14]
S. pombe Cut5/Rad4 4x BRCT. N-terminal pair is shown to bind Drc1. [25, 26]
C. elegans Mus101 6x BRCT. Required for DNA replication. MMS sensitibity by RNAi feeding. SUMO modification? [27]
D. melanogaster Mus101 7x BRCT. Involvement in DNA replication is suggested. [28, 29]
X. laevis Cut5/Mus101 8x BRCT. Functions in DNA replication and DNA replication or damage checkpoints. [30–32]
H. sapiens TopBP1 8x BRCT. Originally isolated as topoisomerase-binding protein. Functions in DNA replication and DNA replication or damage checkpoints. [33–35]