Table 1 Dpb11 orthologues
From: The role of CDK in the initiation step of DNA replication in eukaryotes
Species | Gene product | Features |
|---|---|---|
S. cerevisiae | Dpb11 | 4x BRCT. N-terminal and C-terminal pair binds phosphorylated Sld3 and phosphorylated Sld2, respectively. [6, 12, 14] |
S. pombe | Cut5/Rad4 | 4x BRCT. N-terminal pair is shown to bind Drc1. [25, 26] |
C. elegans | Mus101 | 6x BRCT. Required for DNA replication. MMS sensitibity by RNAi feeding. SUMO modification? [27] |
D. melanogaster | Mus101 | 7x BRCT. Involvement in DNA replication is suggested. [28, 29] |
X. laevis | Cut5/Mus101 | 8x BRCT. Functions in DNA replication and DNA replication or damage checkpoints. [30–32] |
H. sapiens | TopBP1 | 8x BRCT. Originally isolated as topoisomerase-binding protein. Functions in DNA replication and DNA replication or damage checkpoints. [33–35] |