From: The role of CDK in the initiation step of DNA replication in eukaryotes
Species | Gene product | Features |
---|---|---|
S. cerevisiae | Sld3 | Binds to Cdc45, GINS and Dpb11. Phosphorylation at T600 and S622 by CDK is essential for initiation. Phosphorylated Sld3 binds Dpb11 N-terminus. Alanine-substitution mutant is lethal. [5, 6] |
S. pombe | Sld3 | Required for initiation (Cdc45 loading). Chromatin loading of Sld3 depends on DDK but not CDK. [24] |