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Table 3 Sld3 orthologues

From: The role of CDK in the initiation step of DNA replication in eukaryotes

Species Gene product Features
S. cerevisiae Sld3 Binds to Cdc45, GINS and Dpb11. Phosphorylation at T600 and S622 by CDK is essential for initiation.
Phosphorylated Sld3 binds Dpb11 N-terminus. Alanine-substitution mutant is lethal. [5, 6]
S. pombe Sld3 Required for initiation (Cdc45 loading). Chromatin loading of Sld3 depends on DDK but not CDK. [24]