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Table 1 Cdt1 degradation directed by CUL4-DDB1CDT2 and SCFSkp2 in different species.

From: Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways

 

Degradation of Cdt1 by

Species

CUL4-DDB1 CDT2

SCF Skp2

Human

Yes

Yes

Mice

Yes

(No?)a

Frogs

Yes

No

Flies

Yes

?b

Nematodes

Yes

No

Fission yeast

Yes

Noc

  1. a Available evidence suggests that SCFSkp2 does not direct Cdt1 degradation in mice, however direct experiments have not been performed (see text).
  2. b No published studies have addressed the role of Skp2 in Drosophila.
  3. c Fission yeast lack a recognizable Skp2 homolog.
  4. See text for references and discussion.
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Cell Division

ISSN: 1747-1028

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