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Table 2 Conservation of CUL4-DDB1CDT2 and SCFSkp2 components in prokaryotic and eukaryotic species.

From: Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways

Group

Phylum or Division

Species

Cullins*

DDB1

CDT2

Skp1

Skp2

Eubacteria

Aquificae

Aquifex aeolicus

-

-

-

-

-

 

Firmicutes

Bacillus subtilis

-

-

-

-

-

 

Proteobacteria

Escherichia coli

-

-

-

-

-

Archaea

Crenarchaeota

Aeropyrum pernix

-

-

-

-

-

 

Euryarchaeota

Methanocaldococcus jannaschii

-

-

-

-

-

Protist

Apicomplexa

Plasmodium falciparum

2 (1, 4)

-

-

 

Euglenozoa

Leishmania infantum

7 (1, 1, 3, 3, 3, 4, 4)

-

-

Slime Mold

Amoebozoa

Dictyostelium discoideum

5 (1, 1, 1, 3, 4)

-

-

Plant

Magnoliophyta

Arabidopsis thaliana

9 (1, 3, 3, 3, 4, 4, 4, 4, 4)

-

 

Magnoliophyta

Oryza sativa

9 (1, 3, 3, 3, 3, 4, 4, 4, 4)

-

Fungi

Ascomycota

Saccharomyces cerevisiae

3 (1, 2, 3)

-

-

-

 

Ascomycota

Schizosaccharomyces pombe

3 (1, 3, 4)

-

 

Basidiomycota

Cryptococcus neoformans

7 (1, 1, 1, 1, 3, 3, 4)

-

Invertebrate

Nematoda

Caenorhabditis elegans

6 (1, 1, 2, 3, 4, 5)

 

Arthropoda

Drosophila melanogaster

5 (1, 1, 2, 3, 4)

Vertebrate

Chordata

Danio rerio

8 (1, 1, 1, 2, 3, 3, 4, 4)**

 

Chordata

Xenopus laevis

6 (1, 1, 2, 3, 3, 4)

Mammalian

Chordata

Mus musculus

6 (1, 2, 3, 4, 4, 5)

 

Chordata

Bos taurus

6 (1, 2, 3, 4, 4, 5)

 

Chordata

Homo sapiens

7 (1, 2, 3, 4, 4, 5, 7)

  1. A recognizable homolog in the species is designated by a check mark, and the absence of a homolog by a dash.
  2. * The number of cullins is recorded in each organism. The metazoan cullin (CUL1-CUL5) for which each cullin is most related (by reciprocal BLAST analysis) is indicated in parentheses (e.g., 2 (1, 4) = two cullins that are most related to CUL1 and CUL4, respectively). The divergent CUL7 is listed separately for humans.
  3. **For Danio rerio (zebrafish), genes that were predicted to encode cullin proteins of less than 100 amino acids were not included.