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Table 2 Conservation of CUL4-DDB1CDT2 and SCFSkp2 components in prokaryotic and eukaryotic species.

From: Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways

Group Phylum or Division Species Cullins* DDB1 CDT2 Skp1 Skp2
Eubacteria Aquificae Aquifex aeolicus - - - - -
  Firmicutes Bacillus subtilis - - - - -
  Proteobacteria Escherichia coli - - - - -
Archaea Crenarchaeota Aeropyrum pernix - - - - -
  Euryarchaeota Methanocaldococcus jannaschii - - - - -
Protist Apicomplexa Plasmodium falciparum 2 (1, 4) - -
  Euglenozoa Leishmania infantum 7 (1, 1, 3, 3, 3, 4, 4) - -
Slime Mold Amoebozoa Dictyostelium discoideum 5 (1, 1, 1, 3, 4) - -
Plant Magnoliophyta Arabidopsis thaliana 9 (1, 3, 3, 3, 4, 4, 4, 4, 4) -
  Magnoliophyta Oryza sativa 9 (1, 3, 3, 3, 3, 4, 4, 4, 4) -
Fungi Ascomycota Saccharomyces cerevisiae 3 (1, 2, 3) - - -
  Ascomycota Schizosaccharomyces pombe 3 (1, 3, 4) -
  Basidiomycota Cryptococcus neoformans 7 (1, 1, 1, 1, 3, 3, 4) -
Invertebrate Nematoda Caenorhabditis elegans 6 (1, 1, 2, 3, 4, 5)
  Arthropoda Drosophila melanogaster 5 (1, 1, 2, 3, 4)
Vertebrate Chordata Danio rerio 8 (1, 1, 1, 2, 3, 3, 4, 4)**
  Chordata Xenopus laevis 6 (1, 1, 2, 3, 3, 4)
Mammalian Chordata Mus musculus 6 (1, 2, 3, 4, 4, 5)
  Chordata Bos taurus 6 (1, 2, 3, 4, 4, 5)
  Chordata Homo sapiens 7 (1, 2, 3, 4, 4, 5, 7)
  1. A recognizable homolog in the species is designated by a check mark, and the absence of a homolog by a dash.
  2. * The number of cullins is recorded in each organism. The metazoan cullin (CUL1-CUL5) for which each cullin is most related (by reciprocal BLAST analysis) is indicated in parentheses (e.g., 2 (1, 4) = two cullins that are most related to CUL1 and CUL4, respectively). The divergent CUL7 is listed separately for humans.
  3. **For Danio rerio (zebrafish), genes that were predicted to encode cullin proteins of less than 100 amino acids were not included.