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Figure 1 | Cell Division

Figure 1

From: Can eukaryotic cells monitor the presence of unreplicated DNA?

Figure 1

Overview of replication fork conditions that could trigger a checkpoint response. Inhibition of DNA replication by nucleotide depletion or DNA damage, and unfired licensed origins trigger S phase checkpoint activation, whereas unreplicated centromeres could trigger the activation of the spindle checkpoint due to lack of tension at kinetochores. However unreplicated segments of DNA in non-centromeric sites and the presence of forks at natural protein-DNA complexes, like the RFB sites on rDNA genes, do not trigger a checkpoint response.

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