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Table 1 Proteins that use an LXCXE interaction motif to bind to pRB

From: Structure-function analysis of the retinoblastoma tumor suppressor protein – is the whole a sum of its parts?

Protein

Biochemical Functions

References

AhR

Aryl hydrocarbon receptor

[158]

ASK1

Ser/Thr kinase

[159]

Bog

Unknown

[160]

BRG1

ATP dependent helicase

[161]

Brm

ATP dependent helicase

[110]

CtIP

Transcriptional repressor

[84]

Cyclin D1

kinase regulatory subunit

[162]

Cyclin D2

kinase regulatory subunit

[163]

Cyclin D3

kinase regulatory subunit

[164]

DNA Pol delta

DNA polymerase

[165]

DNMT1

DNA methyltransferase

[20]

EID-1

Unknown

[85] [86]

ELF1

Transcription factor

[87]

HBP1

Transcriptional repressor

[88] [89]

HP1

trimethyl histone H3 binding protein

[19]

HDAC1

histone demethylase

[21] [22] [80]

HDAC2

histone deacetylase

[81]

Hec1

Unknown

[166]

Hsp75

Heat-shock protein

[167]

p202

Unknown

[168]

p204

DNA replication

[169]

RFC p145

DNA replication

[170]

RBP1

Chromatin remodeling/transcriptional repression

[82]

RBP2

histone demethylase

[82]

RIM

Unknown

[171]

RIZ

methyltransferase

[83] [172]

Suv39h1

methyltransferase

[19]

UBF

PolI transcription factor

[90]