Figure 4

Fbw7 isoforms interact in cells (2). Cytoplasmic versions of Fbw7α (A) and Fbw7γ (B) lacking their according nuclear localization signals (NLS) were co-expressed with Myc-tagged Fbw7α or the dimerization mutant and cover slips co-stained with Flag and Myc antibodies. All images in are representatives of at least three independent experiments and were also carried out in 293A cells (not shown).