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Table 1 Alignment of CPDs.

From: Fbw7/hCDC4 dimerization regulates its substrate interactions

Conservation of the negative charge in the +4 position of CPDs

  

0 +4

 

references

cyclin E:

T380

LLT PPQS GK

mammalian

(1–3)

 

T62

IPT PDKE DD

 

(3)

c-Myc :

T58

LPT PPLS PS

 

(4,5)

c-Jun:

T239

GET PPLS PI

 

(22)

SREBP 1:

T456*

TLT PPPS DA

 

(10)

SV40/Large T:

T701

PPT PPPE PE

 

(21)

Notch 1:

T2512*

FLT PSPE SP

  

Presenilin 1:

T116

IYT PFTE DT

  

Gcn4:

T165

LPT PVLE DA

yeast

(23)

Far1 :

S87

PIS PPPS LK

 

(24)

Cdc6:

T39

DVT PESS PE

 

(25)

 

T368

PLT PTTS PV

 

(25)

Clb6:

S6

IPS PISE RK

 

(26)

 

T39

NLT PHST NE

 

(26)

Rum1 :

T58

PPT PAKT PK

 

(27)

  1. Every CPD contains a central phospho-threonine (except of Far1 and Clb6) followed by proline and a negative charge in the +4 position (glutamate or phosphosite). Large T is assigned to the mammalian CPDs, because it targets Fbw7. The CPDs for Notch and Presenilin have not been published yet and are putative. (*) indicates the amino acid position in full-length proteins before cleavage. Exceptions to the +4 negative charge rule are most CPDs of Sic1, Tec1, Hap1, CDC18 and Cig2 all of which contain multiple low-affinity degrons (not shown).
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Cell Division

ISSN: 1747-1028

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