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Table 1 Alignment of CPDs.

From: Fbw7/hCDC4 dimerization regulates its substrate interactions

Conservation of the negative charge in the +4 position of CPDs
   0 +4   references
cyclin E: T380 LLT PPQS GK mammalian (1–3)
  T62 IPT PDKE DD   (3)
c-Myc : T58 LPT PPLS PS   (4,5)
c-Jun: T239 GET PPLS PI   (22)
SREBP 1: T456* TLT PPPS DA   (10)
SV40/Large T: T701 PPT PPPE PE   (21)
Notch 1: T2512* FLT PSPE SP   
Presenilin 1: T116 IYT PFTE DT   
Gcn4: T165 LPT PVLE DA yeast (23)
Far1 : S87 PIS PPPS LK   (24)
Cdc6: T39 DVT PESS PE   (25)
  T368 PLT PTTS PV   (25)
Clb6: S6 IPS PISE RK   (26)
  T39 NLT PHST NE   (26)
Rum1 : T58 PPT PAKT PK   (27)
  1. Every CPD contains a central phospho-threonine (except of Far1 and Clb6) followed by proline and a negative charge in the +4 position (glutamate or phosphosite). Large T is assigned to the mammalian CPDs, because it targets Fbw7. The CPDs for Notch and Presenilin have not been published yet and are putative. (*) indicates the amino acid position in full-length proteins before cleavage. Exceptions to the +4 negative charge rule are most CPDs of Sic1, Tec1, Hap1, CDC18 and Cig2 all of which contain multiple low-affinity degrons (not shown).