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Table 2 Mammalian H2A E3 ubiquitin ligases

From: The many faces of ubiquitinated histone H2A: insights from the DUBs

E3 ligase

Domain structure

Substrate

Interactors

Process

Ref.

Ring1A/RING1, Ring1B/RNF2

RING

H2A

PRC1; E2F-6; Fbxl10/BcoR complexes

Repression of transcription

[11-14, 30-32,86,87]

RNF8

FHA, RING

H2A/H2AX

n.d.

DNA damage response; G2/M transition

[18,19,54,55,63,84,85]

2A-HUB/KIAA0675/hRUL138/DZIP3

RING

H2A

N-CoR, HDAC1, HDAC3

Repression of specific chemokine genes

[40]

  1. Abbreviations: PRC1, Polycomb Repressive Complex 1; Fbxl10, F-box and leucine-rich repeat protein 10 (JHD1B); BcoR, BCL6 co-repressor; RNF8, Ring Finger protein 8; FHA, forkhead-associated phosphopeptide-binding domain; N-CoR, Nuclear receptor Co-Repressor; HDAC, Histone De-Acetylase; n.d., not determined.
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Cell Division

ISSN: 1747-1028

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