Figure 3

Modulation of the steady-state levels of mRNAs for selected nucleotide biosynthetic enzymes by the different classes of human herpesviruses. Microarray data for virus-infected cells was mined to illustrate the extent to which cellular nucleotide biosynthetic enzymes were activated upon infection with the indicated viruses. See text for a detailed discussion. HSV-1 infection of mouse embryonic fibroblasts at 4, 8, and 12 hours post infection (hpi) [317], left lane. HSV-1 infection of rat superior cervical ganglia neurons at 6, 12, and 24 hpi (Szpara and Enquist, personal communication), right lane. HCMV infection of human foreskin fibroblasts at 20, 24, and 48 hpi [316]. KSHV infection and reactivation of endothelial cells at 24, 37, and 48 hpi [315]. Red, up-regulated 2-fold or more in at least two out of three time points. Green, down-regulated 2-fold or more in at least two out of three time points. Black, any changes were less than 2-fold. Grey, not analyzed/not found. In cases where more than one probe set was present, fulfillment of above criteria by any one probe set was sufficient.