Figure 1

Hyper-filamentous, temperature sensitive cdc28 mutants exhibit altered Cks1-binding region. The three-dimensional structure of Cdc28 was modeled from the crystal structure of human CDK2 [3]. Each allele is listed with amino acid substitutions color coded according to the functional region of the molecule in which it lies: yellow = Cks1 binding, orange = non-surface residues underlying the Cks1-binding domain, green = ATP-binding, red = cyclin-binding, white = uncharacterized structure function relationship, striped = ATP.