Table 1 RBX1-Cullins E3 ubiquitin ligases and their substrates in mammals

RBX1/Cullin-1/SKP1/F-Box proteins

e.g. p21, p27, p57, Cyclins A/D/E, E2F1, Cdc25A/B, PDCC4, FOXO1, Myc, p53, c-Jun, Notch 1/4, IκB, β-Catenin, Orc1, and many more. For near complete list, see cited references

[14, 25, 26]

RBX1/Cullin-2/Elongin BC/VHL

e.g. HIF-α, TEL-JAK2

[27, 28]

RBX1/Cullin-3/BTB-domain proteins

e.g. MEI-1, Dishevelled (Dsh), Nrf2, RhoBTB2, topoisomeraseI-DNA complex, and caspase 8

[29–36]

RBX1/Cullin-4A/DDB1

e.g. p53, TSC2, Cdt1, c-Jun and Merlin

[37–45]

RBX1/Cullin-5/elongin BC/BC-box proteins/SOCS

e.g. Disabled-1 (Dab1)

[46]

RBX1/Cullin-7/SKP1/Fbw8

e.g. Insulin receptor substrate 1 (IRS-1)

[47]