Table 1 Combined disruption of Dido and Ku80 is embryonic lethal.

From: Merotelic attachments and non-homologous end joining are the basis of chromosomal instability

*Ku80*	*Dido*	N° pups (expected)	N° pups (observed)
+/+	+/+	78.75	147
+/+	+/neo	157.50	278
+/+	neo/neo	78.75	49
+/-	+/+	157.50	216
+/-	+/neo	315.00	411
+/-	neo/neo	157.50	88
-/-	+/+	78.75	24
-/-	+/neo	157.50	47
-/-	neo/neo	78.75	0
Total		1260	1260

Mice heterozygous for Dido and Ku80 were crossed and all viable pups were genotyped. Ku80^-/- and Dido^neo/neo pups were born at a lower frequency than heterozygous littermates. No double mutant mice were born in a population of >1000 animals.

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