Heterozygous mutation in the conserved regions of hSMC2 protein identified upon sequencing of cancer genomes. Data is from COSMIC http://www.sanger.ac.uk/genetics/CGP/cosmic/. Only hSMC2 subunit mutations are shown for illustration. Other mutations are: NCAPD2 R698C, NCAPD3 E48G and L759L, NCAPG2 T246I. Alignment was generated and color coding was assigned by ClustalW software.