Figure 7From: One-hit wonders of genomic instability DNA underreplication may result in chromosomal breaks in higher cells. It is likely that yeast, due to their single-microtubule kinetochores, do not sustain substantial number of DSB as a result of chromatid bridging, opting for nondisjunction instead. It is likely, however, that human chromosomes would break, if underreplication zones are still present in anaphase.Back to article page