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Figure 2 | Cell Division

Figure 2

From: Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer

Figure 2

Cyclin E has multiple functions in cell cycle progression, both Cdk-dependent and Cdk-independent. Cyclin E is necessary for the formation of pre-replication complexes on DNA as cells re-enter the cell cycle after quiescence. Cyclin E also activates the Cdk2 holoenzyme, and phosphorylates many targets at the G1 to S phase transition of the cell cycle, including the retinoblastoma protein (Rb). Finally, cyclin E, via its CLS binding motif, interacts with centrosomes and promotes centrosome duplication.

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