From: Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer
 | Cyclin E1 (CCNE1) | Cyclin E2 (CCNE2) |
---|---|---|
Chromosomal location | 19q12 | 8q22.1 |
Isoforms | 2 (Full length and 15 amino acid N-terminal truncation) | 1 |
Transcriptional regulation | Upregulated by: | Upregulated by: |
 | ||
 | ||
 | Suppressed by: | |
 | HDAC1 [58, 62, 63], SUV39H1/HP1 [64, 65], BRG1/hBRM [66], PRMT5/COPR5 [68–71] | CDP/Cux p110 [47] |
 |  | Suppressed by: |
 |  | |
miRNA regulation | ||
Post-translational cleavage | Yes [98] | No [99] |
Tissue expression | Embryonic cells | Embryonic cells |
 |    - Very high in mouse embryonic stem cells [45] |    - Absent in mouse embryonic stem cells [45] |
 |    - Sole E-cyclin from fertilisation to blastula stage in Xenopus [39] |    - Not expressed during embryonic cycles of Xenopus [39] |
 | Adult tissues | Adult tissues |
 |    - Mouse: moderate in brain, testes and thymus, low in intestine and spleen [45] |    - Mouse: high in testes, low to moderate in brain, intestine, muscle and thymus [45] |
 |    - Human: very high in placenta, high in testes, low to moderate in thymus, small intestine and colon [5] |    -Human: high in brain, placenta, testes and thymus, low to moderate in spleen, thymus, small intestine and colon [5] |
 | Polyploid cells | Polyploid cells |
 |    - Low expression in mature trophoblast giant cells [20] |    - Sustained expression in mature trophoblast giant cells [20] |
 |    - Low expression compared to CCNE2 in hepatocytes [44] |    - High expression compared to CCNE1 in hepatocytes [44], increased expression with increased polyploidy [43] |
Knockout mouse | ||
 | Slight delay in liver regeneration following partial hepatectomy [44] | Accelerated liver regeneration and increased hepatocyte polyploidy following partial hepatectomy [44] |