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Table 1 Attributes of the E-cyclins

From: Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer

  Cyclin E1 (CCNE1) Cyclin E2 (CCNE2)
Chromosomal location 19q12 8q22.1
Isoforms 2 (Full length and 15 amino acid N-terminal truncation) 1
Transcriptional regulation Upregulated by: Upregulated by:
  E2F1, E2F2, E2F3 [5557] E2F1, E2F2, E2F3 [5557]
  P300/CBP [58], Src3 [59], Carm1 [60] P300/CBP*, Src3 [61], Carm1 [61]
  Suppressed by: Chd8 [74, 75]
  HDAC1 [58, 62, 63], SUV39H1/HP1 [64, 65], BRG1/hBRM [66], PRMT5/COPR5 [6871] CDP/Cux p110 [47]
   Suppressed by:
   HDAC1*, SUV39H1/HP1*, BRG1/hBRM*, PRMT5/COPR5 [6871]
miRNA regulation miR15b [86], miRNA 16 family [87] miR-9, miR-34c and miR200a [88], miR34a [89], miR26a [90]
Post-translational cleavage Yes [98] No [99]
Tissue expression Embryonic cells Embryonic cells
     - Very high in mouse embryonic stem cells [45]    - Absent in mouse embryonic stem cells [45]
     - Sole E-cyclin from fertilisation to blastula stage in Xenopus [39]    - Not expressed during embryonic cycles of Xenopus [39]
  Adult tissues Adult tissues
     - Mouse: moderate in brain, testes and thymus, low in intestine and spleen [45]    - Mouse: high in testes, low to moderate in brain, intestine, muscle and thymus [45]
     - Human: very high in placenta, high in testes, low to moderate in thymus, small intestine and colon [5]    -Human: high in brain, placenta, testes and thymus, low to moderate in spleen, thymus, small intestine and colon [5]
  Polyploid cells Polyploid cells
     - Low expression in mature trophoblast giant cells [20]    - Sustained expression in mature trophoblast giant cells [20]
     - Low expression compared to CCNE2 in hepatocytes [44]    - High expression compared to CCNE1 in hepatocytes [44], increased expression with increased polyploidy [43]
Knockout mouse Normal fertility [13, 20] Male infertility and testicular atrophy [13, 20]
  Slight delay in liver regeneration following partial hepatectomy [44] Accelerated liver regeneration and increased hepatocyte polyploidy following partial hepatectomy [44]
  1. * by inference from data on CCNE1