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Table 1 Jab1/CSN5-interacting proteins that regulate p27

From: JAB1/CSN5: a new player in cell cycle control and cancer

Protein Description Interaction effect References
PGP9.5 Ubiquitin C-terminal hydrolase p27 degradation [103]
Thioredoxin Cellular redox enzyme that regulates cell growth and apoptosis Inhibits Jab1/CSN5-mediated AP-1 transactivation and Jab1/CSN5-dependent p27 degradation [104]
VDUP1 Tumor suppressor and stress response gene, vitamin D3 up-regulated protein-1 Inhibits Jab1/CSN5-mediated AP-1 transactivation and Jab1/CSN5-dependent p27 degradation [105]
Hepatitis B virus pre-S2 mutant surface antigen Hepatitis B virus large antigen mutant associated with hepatocellular carcinogenesis p27 degradation [106]
  1. Abbreviations: PGP9.5, Protein gene product 9.5; AP-1, activator-protein 1; VDUP1, Vitamin D3 up-regulated protein 1