JAB1/CSN5: a new player in cell cycle control and cancer

Cell Division

Table 1 Jab1/CSN5-interacting proteins that regulate p27

Protein	Description	Interaction effect	References
PGP9.5	Ubiquitin C-terminal hydrolase	p27 degradation	[103]
Thioredoxin	Cellular redox enzyme that regulates cell growth and apoptosis	Inhibits Jab1/CSN5-mediated AP-1 transactivation and Jab1/CSN5-dependent p27 degradation	[104]
VDUP1	Tumor suppressor and stress response gene, vitamin D3 up-regulated protein-1	Inhibits Jab1/CSN5-mediated AP-1 transactivation and Jab1/CSN5-dependent p27 degradation	[105]
Hepatitis B virus pre-S2 mutant surface antigen	Hepatitis B virus large antigen mutant associated with hepatocellular carcinogenesis	p27 degradation	[106]

Abbreviations: PGP9.5, Protein gene product 9.5; AP-1, activator-protein 1; VDUP1, Vitamin D3 up-regulated protein 1

ISSN: 1747-1028