Impact of spindle orientation on asymmetric cell division. Asymmetric cell division is depicted in a hypothetical polarized cell (A) and in budding yeast (B). Only two chromosomes are shown for simplicity. In the upper panels, spindle aligns along the polarity axis and asymmetric cell division ends successfully giving rise to two different cells which carry different cell fate determinants depicted in different colors. In the lower panels, spindle aligns perpendicular to the polarity axis which results in failure of the asymmetric cell division in A and aneuploidy in B. Note that, the site of cell division in budding yeast is determined at G1/S which is before spindle assembly and entry into mitosis. Hence, if budding yeast divides despite the failure of spindle alignment along the polarity axis, inheritance of the cell fate determinants is not affected but aneuploidy occurs.