Intracellular gradients during Interphase. (A), The drosophila syncitial embryo utilizes a gradient of bicoid mRNA (purple) that diffuses from the cephalad pole of the embryo, to the caudal pole. This results in a gradient of translated Bicoid protein (red) as shown in (B). (C), A gradient of Pom1 kinase is localized to the cell tips in S. pombe. As the cell grows, the gradient rescinds from the central region of the cell allowing activation of Cdr2 and downstream activation of Cdk-1 to trigger entry into mitosis (D) .