Figure 2

Schematic diagram of the shared domains for p107, p130, and Rb. p107 and p130 are more similar to each other than to Rb due to more extensive sequence homology and the shared Cyclin binding and Cdk inhibitory domains. Regions of p107 known to be important for specific protein interactions are shown above in blocked lines. The minimal sequences required for binding Sp1 and B-myb have not yet been identified, however the region N-terminal from the pocket domains has been shown to be critical for binding to both proteins.