p107 in the public eye: an Rb understudy and more

Cell Division

Table 1 Summary of functional differences between p107, Rb, and p130.

*Function*	p107	p130	Rb	References
Binds to Smad3	yes	no	no	[77]
Binds to Sp1	yes	no	no	[91]
Binds to c-Myc	yes	unknown	no	[94, 95]
Binds to Cyclins	yes	yes	no	[51, 83–86, 89, 140]
Regulates chrondrocyte development in vivo	yes	yes	no	[58, 102–104, 139]
Regulates neural precursor populations through FGF and Hes1 in vivo	yes	no	no	[105, 108, 112]
Regulates cerebellar granule cell survival	yes	no	yes	[113]
Tumor suppressor	weak	weak	yes	[44, 49, 122, 123, 129, 131–133, 141]

ISSN: 1747-1028