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Table 2 Summary of p107-deficient mouse models and their phenotypes.

From: p107 in the public eye: an Rb understudy and more

Genotype Strategy Lethality Major Phenotypes References
p107 -/- (Balb/c) Germline Viable Ectopic myeloid hyperplasia in the spleen and liver, severe postnatal growth deficiency, fibroblasts and myoblasts have increased cell cycle kinetics, decreased white adipose tissue. [99, 100]
p107 -/- (mixed) Germline Viable No gross abnormalities, expanded neural progenitor pool in the embryonic and adult brain. [105, 108]
Rb +/- ;p107 -/- Germline Viable Pituitary tumors, reduced viability and growth retardation after birth until ~3 months of age, vaginal atresia (females). [50]
Rb +/- ;p107 -/- Chimera Viable Pituitary glad tumors, adenocarcinoma of the caecum, osteosarcoma, lymphosarcoma, occasional retinal dysplasia but no retinoblastoma. [130]
Rb -/- ;p107 -/- Chimera Viable Retinoblastoma development between 1 - 3 months of age, adult mice obtained at low frequency, apoptosis in the retina. [130]
Rb -/- ;p107 -/- Germline Lethal E11.5 Accelerated apoptosis in the liver and CNS. [97]
Mox2Cre;Rb lox/lox ;p107 -/- Conditional (embryo) Lethal E13.5-E14.5 Hyperproliferation of the CNS, lens, blood vessel endothelial cells. Double-outlet right ventricle (DORV) heart defect. [142]
p107 -/- ;p130 -/- Germline Birth Hyperproliferation of chondrocytes, defective endochondral bone development, increased epidermal proliferation, decreased number of hair follicles, developmental delay in whisker, hair, and tooth formation. [101, 102]
Rb -/- ;p107 -/- ;hIRBPp53DD Chimera Viable Retinoblastoma. [44]
SPC-rtTA;tetCre;Rb lox/lox ;p107 -/- Conditional (lung) Viable ~70% of mice develop lung adenoma or adenocarcinoma. [126]
K14Cre;Rb lox/lox ;p107 -/- Conditional (skin) Viable Spontaneous squamous cell carcinomas. [49]
NesCre;Rb lox/lox ;p107 -/- Conditional (retina) Viable Retinal dysplasia, high levels of apoptosis in the retina. [129]
Chx10Cre;Rb lox/lox ;p107 -/- Conditional (retina) Viable Unilateral retinoblastoma, 60% penetrant, delayed onset compared to Rb/p53/p107. [132]
Chx10Cre;Rb lox/lox ;p53 lox/lox ; p107 -/- Conditional (retina) Viable Aggressive bilateral retinoblastoma, 100% penetrant. [132, 141]
Chx10Cre;Rb lox/lox ;p130 -/- ;p107 +/- Conditional (retina) Viable Differentiated horizontal neurons of the Inner Nuclear Layer re-enter the cell cycle and form metastatic retinoblastoma. [133]
Pax6α Cre;Rb lox/lox ;p107 -/- Conditional (retina) Viable Unilateral retinoblastoma, 60% penetrant, delayed onset compared to Rb/p130. [131, 143]
En2Cre;Rb lox/lox ;p107 -/- Conditional (dorsal mid-hindbrain) Viable Ataxia between P15 and P20, disorganized cerebellar architecture, shrunken dendritic arborization, laminar defects, hyperproliferation of granule cell precursors, and granule cell death upon differentiation. [113]
p107 -/- ;p27 D 51/D 51 Germline Viable Chondrocyte hyperproliferation, defective chondrocyte maturation, defective endochondral bone formation. [103]
Hes1 -/- ;p107 -/- Germline Lethal E12.5 Embryonic lethality due to null Hes1 mutation, restoration of normal numbers of neural precursors in embryos and adults. [108]