Genetic alteration | Deregulated Cdk | Reference |
---|
Oncogenes
| Â | Â |
Cyclin D1 | Cdk2, Cdk4 | [141, 142] |
ErbB2 | Cdk4 | [139] |
Ras | Cdk4 | [22, 140] |
Tumor Suppressors
| Â | Â |
E2F3a/b | Cdk2 | [33] |
MEK2 | Cdk4, Cdk6 | [136] |
p16INK4A
| Cdk4, Cdk6 | [143, 145] |
p21Waf1/CIP1
| Cdk2, Cdk4 | [118, 119, 121, 122] |
p53 | Cdk2, Cdk4 | [86, 120, 121] |
Skp2 | Cdk2 | [125] |
Rb | Cdk2 | [82] |