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Table 1 Oncogenes and inactive tumor suppressors and the G1 phase Cdk they may deregulate to signal centrosome amplification.

From: The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification

Genetic alteration

Deregulated Cdk

Reference

Oncogenes

  

Cyclin D1

Cdk2, Cdk4

[141, 142]

ErbB2

Cdk4

[139]

Ras

Cdk4

[22, 140]

Tumor Suppressors

  

E2F3a/b

Cdk2

[33]

MEK2

Cdk4, Cdk6

[136]

p16INK4A

Cdk4, Cdk6

[143, 145]

p21Waf1/CIP1

Cdk2, Cdk4

[118, 119, 121, 122]

p53

Cdk2, Cdk4

[86, 120, 121]

Skp2

Cdk2

[125]

Rb

Cdk2

[82]