Figure 2

Mutation of serine 88 to phenylalanine in Cdc25A induces early embryonic lethality in mice. A) Heterozygous mutant mice carrying a serine 88 to phenylalanine mutation were mated and the resulting pups were genotyped. No homozygous mutant mice were obtained in the progeny. B) Further analysis shows that the earliest live homozygous embryos were obtained at the blastocyst stage (day E3.5).