Links between cellular signaling pathways and cell cycle control via translational regulation. Cell growth stimulating factors activate the mTOR and Ras/Raf-MAPK signaling pathways. These two signaling cascades may regulate translation of cell cycle regulatory factors by modulating the activity of some translation factors, and thereby promote cell cycle progression and cell survival. Negative environmental factors may inhibit cell cycle also by targeting the translation factors. Different signaling pathways may have common targets to coordinate cell cycle regulation. Note that this simplified schematic diagram only illustrates the factors described in the text. Kinases and translation factors are labeled in orange and blue.