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Figure 1 | Cell Division

Figure 1

From: Centriole assembly and the role of Mps1: defensible or dispensable?

Figure 1

Centriole assembly as a modular process. Centriole assembly in human cells proceeds through a pathway analogous to that described in C. elegans, but requires several additional proteins not present in worms, and proceeds through a cartwheel template as opposed to a central tube. Centrioles are not templates per se, but rather provide a surface for the assembly of cartwheels, depicted as a hub composed of hSas6 (red) and 9 symmetrical spokes (blue). We propose that cartwheels then serve as a platform onto which additional centriole modules are assembled in a proximal to distal, or "bottom-up" fashion. Yellow and green rectangles are used to depict proximal (yellow) and distal (green) centriole modules. The frame surrounding these modules is meant to depict maturation into the final structure rather than centriolar microtubules.

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