Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A

Table 2 Ten most down- or up-regulated genes in CCRF-CEM cells after treatment guieranone A

ID	Symbol	Description	Fold Change
*Up-regulated genes*
160092	HSPA6	heat shock 70 kDa protein 6 (HSP70B)	11.43
290730	HIST1H2BD	histone cluster 1, H2bd	8.00
7160239	FOSB	FBJ murine osteosarcoma viral oncogene homolog B	5.39
1820592	HIST2H2AA4	histone cluster 2, H2aa4	4.45
20129	CD52	CD52 molecule	4.16
610451	HIST2H2AA4	histone cluster 2, H2aa4	4.07
6510367	JUN	jun oncogene	3.86
6660601	HMOX1	heme oxygenase (decycling) 1	3.64
1500600	RAB37	RAB37, member RAS oncogene family	3.34
6860072	TRAPPC6A	trafficking protein particle complex 6A	3.29
*Down-regulated genes*
2850020	DHRS2	dehydrogenase/reductase (SDR family) member 2	−4.17
3420400	KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	−4.18
4230196	KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	−4.48
460286	THOC4	THO complex 4	−4.50
4390315	HNRNPA1P2	heterogeneous nuclear ribonucleoprotein A1 pseudogene 2	−4.77
2750719	DDX21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	−4.91
4890671	DHRS2	dehydrogenase/reductase (SDR family) member 2	−5.68
4880646	ACTBL3	actin, beta-like 3	−5.70
3940592	PGAM1	phosphoglycerate mutase 1 (brain)	−5.76
5270730	ACTB	actin, beta	−6.50

ISSN: 1747-1028