Table 1 Comparison of amino acid sequences between the corresponding Fn3 domains containing AVNKYG sequence in human (Q8WZ42),mouse (A2ASS6) and zebrafish (A5X6X5) titin molecule

19*

H.s 16425-16509

PS PPRN L AVTD IKAESC Y L T WDAPLD NGGSE I T H YVIDKR D ASRKKA EWE E VTNTAV E K RYG I W K L IPN G QYE FRV R AVNKYG IS

19

M.m 17287-17371

PS PPRN L AVTD IKAESC Y L TWDAPLD N GGSE I T H YIIDKR D ASRKKS EWEE VTNTAV E R RYG I W K L IPN G QYE FRV R AVNKYG IS

19

D.r 15268-15355

PT PPRN V AVSS IKAESCN L S WDAPLD I GGSEL T N YIVEMKD LNVEDP E KA E WVQVTKSII EK RYGVWN L VTG G NYKFRV K A ENKYG IS

63

H.s 22482-22565

PGPPEGPL A V TEV T S EKCVLSW F PPL D DGG A KI DH YI V Q K RETSRL A WTNVA SEV QV TKL KVTKLLKGNEYIFRV K AVNKYG VG

63

M.m 23344-23427

PGPPEGPL A V SDV T S EKCVLSW L PPL D DGG A KI DH YI V Q K RETSRL A WTNVA TEV QV TKL KVTKLLKGNEYIFRV M AVNKYG VG

62

D.r 21291-21374

PGPPEGPL H V TDM T V EKCVLSW L PPL H DGG G KI EY YI I Q R RETSRL T WTNVA TDL QV NRY KVTKLLKGNEYIFRV M AVNKYG VG

71

H.s 23546-23647

PGPP E GP VV I S GVT A EKC TLA WK P PL Q DGG SDIIN YIVERRETSRLVWT V V DAN VQTL SCKVT KLL E GNEY T FR IM AVNKYG V G

71

M.m 24426-24509

PGPP E GP VA I S GVT AEKC TLA WK P PL Q DGG SDITN YIVERRETSRLVWT L V DAN VQTL SCKVL KLL E GNEY I FR IM AVNKYG V G

70

D.r 22373-22456

PGPP D GP IS I Y GVT S EKC CIS WK T PL H DGG AEVSH YIVERRETSRLVWT V V ELK VQTL NLK IT KLL P GNEY I FR VI PVNKYG I G

79

H.s 24646-24729

PGPPEGP VQ V T GVT S EKC S L T W S PP LQ DGGS D IS H YV VE KRETSRLAWTVV ASEVVTNSL KVTKLL E GN E YV FR I M AVNKYG VG

79

M.m 25508-25591

PGPPEGP VQ V T GVT A EKC T L A W S PP LQ DGGS DIS H YV VE KRETSRLAWTVV ASEVVTNSL KVTKLL E GN K Y I FR I M AVNKYG VG

78

D.r 23454-23537

PGPPEGP LT V S GVT N EKC S L S W L PP RH DGGS S IS Y YV IQ KRETSRLAWTVV SGDCGATMFKVTKLL KGN E Y I FR VM AVNKYG VG

87

H.s 25729-25812

PGPP E GPLKVTGV T AEKCYL A W NP P LQ DGGA N ISHYIIEKRETSRLSWT Q V STEV QA LN YKVTKLLPGNEYIFRVM AVNKYG IG

87

M.m 26591-26674

PGPP E GPLKVTGV T AEKCYL A W NP P LQ DGGA S ISHYIIEKRETSRLSWT Q V SNEV QA LN YKVTKLLPGNEYIFRVM AVNKYG IG

86

D.r 24537-24620

PGPP D GPLKVTGV A AEKCYL H W SH P SH DGGA S ISHYIIEKRETSRLSWT V V EPKI QA IS YKVTKLLPGNEYIFRVM AVNKYG IG

103

H.s 27893-27976

PGPP GGP I E FK V TA EKI T LL W R PPAD D GGA KI THYIVEKRETSR VV WS MVS E HLEE CI IT TTKI IKGNEY I FRVR AVNKYG I G

103

M.m 28755-28838

PGPP GGP I E FK V TA EKI T L LW R PPAD D GGA KI THYIVEKRETSR VV WS MVA E NLEE CI T TTKI IKGNEY V FRVR AVNKYG I G

102

D.r 26701-26784

PGPP AGE I Q FK I TA DTM T IM W D PPAD E GGA MV THYIVEKRETSR IM WS IIS E KLQD CI T VPRLIKGNEY I FRVR GVNK HG VG

119

H.s 30068-30150

PGP CGKLTVS RVT Q EKCT LA W SL P Q EDGG AEIT HYIVERRETSRLNWVI V E G EC P T L S Y V VTR LIKNNEY I FRVR AVNKYG PG

119

M.m 30930-31012

PGP CGKLTV RVT E EKCT LA W S LP Q EDGG AEIT HYIVERRETSRLNWVI V E G EC L T A S Y V VTR LIKNNEY T FRVR AVNKYG LG

118

D.r 28873-28957

PGP PAGTITIS RVT D EKCT VS W K I P L EDGG DHVS HYIVERRETSRLNWVI M E T EC K T L S C V STK LIKNNEY I FRVR GVNKYG PG