Skip to main content

Table 1 Comparison of amino acid sequences between the corresponding Fn3 domains containing AVNKYG sequence in human (Q8WZ42),mouse (A2ASS6) and zebrafish (A5X6X5) titin molecule

From: Epitope of titin A-band-specific monoclonal antibody Tit1 5 H1.1 is highly conserved in several Fn3 domains of the titin molecule. Centriole staining in human, mouse and zebrafish cells

No’s of Fn3, species and location of Fn3 domains Amino acid sequences of Fn3 domains of titin. The data according to SMART: Fn3 annotation http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00060
19* H.s 16425-16509 PS PPRN L AVTD IKAESC Y L T WDAPLD NGGSE I T H YVIDKR D ASRKKA EWE E VTNTAV E K RYG I W K L IPN G QYE FRV R AVNKYG IS
19 M.m 17287-17371 PS PPRN L AVTD IKAESC Y L TWDAPLD N GGSE I T H YIIDKR D ASRKKS EWEE VTNTAV E R RYG I W K L IPN G QYE FRV R AVNKYG IS
19 D.r 15268-15355 PT PPRN V AVSS IKAESCN L S WDAPLD I GGSEL T N YIVEMKD LNVEDP E KA E WVQVTKSII EK RYGVWN L VTG G NYKFRV K A ENKYG IS
63 H.s 22482-22565 PGPPEGPL A V TEV T S EKCVLSW F PPL D DGG A KI DH YI V Q K RETSRL A WTNVA SEV QV TKL KVTKLLKGNEYIFRV K AVNKYG VG
63 M.m 23344-23427 PGPPEGPL A V SDV T S EKCVLSW L PPL D DGG A KI DH YI V Q K RETSRL A WTNVA TEV QV TKL KVTKLLKGNEYIFRV M AVNKYG VG
62 D.r 21291-21374 PGPPEGPL H V TDM T V EKCVLSW L PPL H DGG G KI EY YI I Q R RETSRL T WTNVA TDL QV NRY KVTKLLKGNEYIFRV M AVNKYG VG
71 H.s 23546-23647 PGPP E GP VV I S GVT A EKC TLA WK P PL Q DGG SDIIN YIVERRETSRLVWT V V DAN VQTL SCKVT KLL E GNEY T FR IM AVNKYG V G
71 M.m 24426-24509 PGPP E GP VA I S GVT AEKC TLA WK P PL Q DGG SDITN YIVERRETSRLVWT L V DAN VQTL SCKVL KLL E GNEY I FR IM AVNKYG V G
70 D.r 22373-22456 PGPP D GP IS I Y GVT S EKC CIS WK T PL H DGG AEVSH YIVERRETSRLVWT V V ELK VQTL NLK IT KLL P GNEY I FR VI PVNKYG I G
79 H.s 24646-24729 PGPPEGP VQ V T GVT S EKC S L T W S PP LQ DGGS D IS H YV VE KRETSRLAWTVV ASEVVTNSL KVTKLL E GN E YV FR I M AVNKYG VG
79 M.m 25508-25591 PGPPEGP VQ V T GVT A EKC T L A W S PP LQ DGGS DIS H YV VE KRETSRLAWTVV ASEVVTNSL KVTKLL E GN K Y I FR I M AVNKYG VG
78 D.r 23454-23537 PGPPEGP LT V S GVT N EKC S L S W L PP RH DGGS S IS Y YV IQ KRETSRLAWTVV SGDCGATMFKVTKLL KGN E Y I FR VM AVNKYG VG
87 H.s 25729-25812 PGPP E GPLKVTGV T AEKCYL A W NP P LQ DGGA N ISHYIIEKRETSRLSWT Q V STEV QA LN YKVTKLLPGNEYIFRVM AVNKYG IG
87 M.m 26591-26674 PGPP E GPLKVTGV T AEKCYL A W NP P LQ DGGA S ISHYIIEKRETSRLSWT Q V SNEV QA LN YKVTKLLPGNEYIFRVM AVNKYG IG
86 D.r 24537-24620 PGPP D GPLKVTGV A AEKCYL H W SH P SH DGGA S ISHYIIEKRETSRLSWT V V EPKI QA IS YKVTKLLPGNEYIFRVM AVNKYG IG
103 H.s 27893-27976 PGPP GGP I E FK V TA EKI T LL W R PPAD D GGA KI THYIVEKRETSR VV WS MVS E HLEE CI IT TTKI IKGNEY I FRVR AVNKYG I G
103 M.m 28755-28838 PGPP GGP I E FK V TA EKI T L LW R PPAD D GGA KI THYIVEKRETSR VV WS MVA E NLEE CI T TTKI IKGNEY V FRVR AVNKYG I G
102 D.r 26701-26784 PGPP AGE I Q FK I TA DTM T IM W D PPAD E GGA MV THYIVEKRETSR IM WS IIS E KLQD CI T VPRLIKGNEY I FRVR GVNK HG VG
119 H.s 30068-30150 PGP CGKLTVS RVT Q EKCT LA W SL P Q EDGG AEIT HYIVERRETSRLNWVI V E G EC P T L S Y V VTR LIKNNEY I FRVR AVNKYG PG
119 M.m 30930-31012 PGP CGKLTV RVT E EKCT LA W S LP Q EDGG AEIT HYIVERRETSRLNWVI V E G EC L T A S Y V VTR LIKNNEY T FRVR AVNKYG LG
118 D.r 28873-28957 PGP PAGTITIS RVT D EKCT VS W K I P L EDGG DHVS HYIVERRETSRLNWVI M E T EC K T L S C V STK LIKNNEY I FRVR GVNKYG PG
  1. H.sHomo sapiens; M.m – Mus musculus; D.rDanio rerio (zebrafish) * - the numbers of human and mouse Fn3 domains are coincidental; number 19 is the same in all species compared, but in zebrafish (Danio rerio) starting from Fn3 domain No.63 the numbers of corresponding Fn3 domains are smaller by one number (that is to human and mouse Fn3 domain No.63 corresponds to No.62 in zebrafish, and so on) . See also the explanation on the numeration of Fn3 domains in text. Homologous amino acids in corresponding Fn3 domains between all the three species are in boxes. AVNKYG sequences are underlined and in bold.