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Table 2 Amino acid sequence homology (in%) between the corresponding Fn3 domains containing AVNKYG sequence in human (Q8WZ42),mouse (A2ASS6) and zebrafish (A5X6X5) titin molecule

From: Epitope of titin A-band-specific monoclonal antibody Tit1 5 H1.1 is highly conserved in several Fn3 domains of the titin molecule. Centriole staining in human, mouse and zebrafish cells

Species compared The homology beween AVNKYG containing Fn3 domains in human (Q8WZ42), mouse (A2ASS6) and zebrafish ( Danio rerio - A5X6X5) titin molecule
  19* 63 71 79 87 103 119
H.s/M.m **96.5 (82/85) 94.0 (79/84) 94.0 (79/84) 94.0 (79/84) 97.6 (82/84) 96.4 (81/84) 94.0 (79/83)
H.s./D.r. 46.6-48.2 (41/85-88) 77.4 (65/84) 67.9 (57/84) 71.4 (60/84) 82.1 (69/84) 67.9 (57/84) 72.6-73.1 (61/83-84)
M.m/D.r. 47.7-49.4 (42/85-88) 82.1 (69/84) 67.9 (57/84) 70.2 (59/84) 83.3 (70/84) 65.5 (55/84) 70.2-71.1 (59/83-84)
H.s/M.m/D.r 51.1 76.2 66.7 66.7 79.8 66.7 69.0
  1. H.sHomo sapiens; M.mMus musculus;D.rDanio rerio (zebrafish).* the numbers of human and mouse Fn3 domains compared are the same; number 19 is the same in all species compared, but in zebrafish starting from the Fn3 domain No.63 the numbers of corresponding Fn3 domains are by one number smaller. See also Table 1 and the explanation on the numeration of Fn3 domains in text. ** the percentage of homology is obtained by dividing the number of consensus amino acids by the whole number of amino acids in the Fn3 domain.