Figure 3From: Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance Dual nature of Myc induced DDR. Tumor promoting DDR: Myc engages the replication checkpoint pathway (ATR/CHK1) to allow robust cellular proliferation and avoid cytotoxic DNA damage accumulation. Tumor suppressive DDR: Myc induced DNA damage response triggers tumor suppressive pathways that act as a barrier to malignant transformation.Back to article page