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Table 2 IC 50 of irradiation in breast cancer cell lines with CDK2 or CDK4 knockdown

From: Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis

Cell line

Vector

IC 50

Est. (SE)

P value 1

MCF10A

pLKO.1

1.76 (0.106)

-

 

shCDK2

1.75 (0.103)

0.943

 

shCDK4

1.34 (0.076)

0.005

MDA-MB-231

pLKO.1

1.89 (0.141)

-

 

shCDK2

2.15 (0.158)

0.197

 

shCDK4

1.27 (0.096)

0.003

HCC1806

pLKO.1

1.95 (0.149)

-

 

shCDK2

2.14 (0.173)

0.364

 

shCDK4

0.85 (0.078)

<0.001

MDA-MB-468

pLKO.1

2.04 (0.139)

-

 

shCDK2

2.27 (0.156)

0.252

 

shCDK4

1.25 (0.093)

<0.001

HCC1954

pLKO.1

2.99 (0.301)

-

 

shCDK4

2.02 (0.160)

0.013

  1. 1The p value is based on the comparisons with pLKO.1 group within each cell line.
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Cell Division

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