Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis

Cell Division

Table 4 Comparison of phospho-Histone 3 between control (pLKO.1) and treatment (shCDK4) groups

Cell line	Vector	0 Gy			2 Gy			4 Gy
Cell line	Vector	Mean*	std	P-value†	Mean	std	P-value†	Mean	std	P-value†
MCF10A	pLKO.1	1.229	0.530	0.145	1.737	0.278	0.277	0.823	0.587	0.168
MCF10A	shCDK4	2.001	0.961	0.145	1.560	0.385	0.277	1.498	0.891	0.168
MDA-MB-468	pLKO.1	0.476	0.555	0.462	0.808	0.171	0.256	0.799	0.221	0.249
MDA-MB-468	shCDK4	0.509	0.077	0.462	0.654	0.330	0.256	0.979	0.359	0.249
MDA-MB-231	pLKO.1	0.168	0.160	0.324	0.170	0.176	0.084	0.060	0.104	0.181
	shCDK4	0.342	0.593		0	0		0.257	0.315

* Mean (standard deviation) of % of phospho-Histone 3 positive cells.
† P-value is for comparing in the mean between control and treatment groups in each irradiation dosage.

ISSN: 1747-1028