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Table 5 Comparison of γ-H2AX between control (pLKO.1) and treatment (shCDK4) groups

From: Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis

Cell line Vector 6 hr 12 hr 24 hr
Mean* std P-value† Mean std P-value† Mean std P-value†
MCF10A pLKO.1 3.964 1.839 0.4621 3.926 3.203 0.1512 1.308 0.357 3.964
shCDK4 2.803 2.216 1.583 1.393 1.707 0.643
MDA-MB-468 pLKO.1 2.148 1.176 0.8272 1.831 0.091 0.9269 4.835 5.890 0.1292
shCDK4 1.660 2.104 1.626 1.407 1.273 0.729
MDA-MB-231 pLKO.1 2.518 0.443 0.4119 3.016 1.634 0.6689 1.587 0.562 0.6609
  shCDK4 3.710 2.273   3.630 3.050   2.217 0.173  
  1. * Mean (standard deviation) of the fold change to no radiation.
  2. † P-value is for comparing in the mean fold change no radiation between control and treatment groups.