Table 3 Deregulated centrosome genes

PLK2

polo-like kinase 2

5.82

SGOL1

shugoshin-like 1 (S. pombe)

4.24

CETN2

centrin, EF-hand protein, 2

4.12

AURKA

aurora kinase A

4.01

BRCA1

breast cancer 1, early onset

3.77

CDK1

cyclin-dependent kinase 1

3.50

SON

SON DNA binding protein

3.09

NEK2

NIMA (never in mitosis gene a)-related kinase 2

2.89

RANBP1

RAN binding protein 1

2.82

CEP76

centrosomal protein 76 kDa

2.46

GADD45A

growth arrest and DNA-damage-inducible, alpha

2.40

TMEM67

transmembrane protein 67

2.40

TBCCD1

TBCC domain containing 1

2.36

SASS6

spindle assembly 6 homolog (C. elegans)

2.33

UXT

ubiquitously-expressed, prefoldin-like chaperone

2.27

XPO1

exportin 1 (CRM1 homolog, yeast)

2.13

HAUS2

HAUS augmin-like complex, subunit 2

2.13

CEP192

centrosomal protein 192 kDa

2.03

HAUS7

HAUS augmin-like complex, subunit 7

2.03

SPICE1

spindle and centriole associated protein 1

2.01

CTNNB1

catenin (cadherin-associated protein), beta 1, 88 kDa

1.88

HAUS5

HAUS augmin-like complex, subunit 5

1.65

PAFAH1B1

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45 kDa)

1.50

NDEL1

nudE nuclear distribution E homolog (A. nidulans)-like 1

−1.50

ARHGEF10

Rho guanine nucleotide exchange factor (GEF) 10

−1.76

PKD2

polycystic kidney disease 2 (autosomal dominant)

−1.80

PCM1

pericentriolar material 1

−1.82

CEP250

centrosomal protein 250 kDa

−1.89

PLXNA2

plexin A2

−3.92

SEMA6A

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

−6.99