Increased Cyclin E2 expression is associated with higher levels of replication-dependent histones in breast cancers. Box plots illustrate the change in mRNA expression levels of CCNE2 compared to CCNE1 as replication-dependent (A.) and non-replication-dependent (B.) histone expression increases in 526 breast cancer samples. Breast cancer samples were grouped according to the number of replication dependent and independent histones displaying above median expression. Gene expression was normalized to the median expression of group 0 for each sample. p-values were calculated using a Mann-Whitney-U test. Boxes represent the normalized median expression and the 1st and 3rd quartiles and whiskers extend 1.5x the IQR from median.