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Fig. 2 | Cell Division

Fig. 2

From: Sumo and the cellular stress response

Fig. 2

Regulation of PCNA by ubiquitin and Sumo. When cells are treated with high doses of MMS, PCNA becomes Sumo-modified primarily on K164 and to a lesser extent K127, resulting in recruitment of HR inhibitor Srs2. At lower levels of DNA damage PCNA is ubiquitinated mainly on K164 (and to a lesser degree also on other sites [113, 51]). This promotes lesion bypass in case of monoubiquitination, whereas polyubiquitinated PCNA induces template switching and error-free DNA repair

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