Fig. 3From: Sumo and the cellular stress responseViruses can target the Sumo pathway to disrupt PML-NBs. a, Several components of PML-NBs are targets of Sumo, and multiple Sumo-SIM interactions may promote complex stability. b, The HSV viral protein ICP0 can function as a STUBL to degrade sumoylated PML, thereby disrupting structural integrity of PML-NBsBack to article page