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Fig. 3 | Cell Division

Fig. 3

From: Sumo and the cellular stress response

Fig. 3

Viruses can target the Sumo pathway to disrupt PML-NBs. a, Several components of PML-NBs are targets of Sumo, and multiple Sumo-SIM interactions may promote complex stability. b, The HSV viral protein ICP0 can function as a STUBL to degrade sumoylated PML, thereby disrupting structural integrity of PML-NBs

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