Fig. 5

Multiple mechanisms of transcriptional regulation by Sumo. a, Sumoylation prevents nuclear entry. b, Sumo prevents recruitment of general transcription factors (GTFs). c, Sumo inhibits promoter binding of the transcription factor. d, Sumo competes with other modifications that activate transcription. e, Sumo prevents degradation of an inhibitor of a transcription factor. f, Sumo recruits a transcriptional repressor that silences the local chromatin environment. g, Sumoylation increases the activity of a transcriptional repressor to inhibit transcription