Table 1 The sumoylation machinery in S. cerevisiae and mammals
Protein function | S. cerevisiae | H. sapiens |
|---|---|---|
Sumo | Smt3 | SUMO-1,-2,-3 |
E1 activating enzyme | Aos1•Uba2 | Sae1•Sae2 |
E2 conjugating enzyme | Ubc9 | UBC9 |
E3 ligase | Siz1, Siz2, Cst9, Mms21 | PIAS1,-2,-3,-4; MZIZ1; NSE2; RanBP2; Pc2; MUL1; TOPORS; HDAC4,-7; TRAF7; FUS; RSUME |
Sumo protease | Ulp1, Ulp2 | SENP1,-2,-3,-4,-5,-6,-7; DESI1,-2; USPL1 |