Core component (D. melanogaster protein) | Enzyme | Regulatory sites | Function |
---|---|---|---|
MST1/2 (Hpo) | PI3K/Akt1 | T120-p, T387-p | Prevention of caspase-mediated cleavage of MST1 |
Autophosphorylation | T183-pa | MST activation | |
JNK1 | S82-p | Enhancement of MST1-mediated pro-apoptotic signaling | |
mTOR | T120-p | Loss of MST1 function | |
c-Abl | Y433-p | Inhibition of degradation | |
TAO3b | MST activation | ||
PP2A | T183-depa | ||
CHIP | Ubiquitination | Protein degradation | |
SAV1 (Sav) | MST2 | T26-p, S27-p, S36-p, S269-p | Activation |
SIK2 and SIK3 | S413-pc | Antagonizing Hpo pathway activity | |
LATS1/2(Wts) | MST1/2 | s909-p, T1079-pd | Enzymatic activity |
NUAK1 | s464-p | Protein stability | |
KIBRA | T1079-pd | Kinase activity | |
Itch | Ubiquitination | Protein degradation | |
CRL4DCAF1 | Ubiquitination | Protein degradation | |
LATS1 | WWP1 | Ubiquitination | Protein degradation |
Nedd4 | Ubiquitination | Protein degradation | |
LATS2 | CHK1/2 | S408-p | Cell cycle regulation, apoptosis |
SIAH1/2 | Ubiquitination | Protein degradation | |
Aurora A | S83-p, S380-p | Intracellular localization | |
MOB1A, MOB1B (Mats) | MTS1/2 | T12-p, T35-p, T74-p | Molecular association |
praja2 | Ubiquitination | Protein degradation | |
YAP (Yki) | LATS1/2 | S61-p, S109-p, S164-p | The cytoplasmic retention |
S127-p | The binding of 14-3-3 | ||
S397-pe | Facilitates the binding of CK1δ/ε, leading to further serine phosphorylations | ||
CK1ε/δ | S400-p, S403-pf | Generates a “phosphodegron” together with S397 | |
c-Abl | Y407-pg | Promotes p73-dependent pro-apoptotic transcription | |
Src/YES1 | Y407-p | Induces assembly of the β-catenin–YAP complex | |
CDK1 | T119-p, S289-p, S367-p | Cell cycle regulation | |
NDR1/2 | S127-p | The cytoplasmic retention | |
JNK | T119-p, S138-p, T154-p, S317-p, T362-p | Inducing YAP to play dual role in different cell contexts | |
SCFβ-TRCP | Ubiquitination | Protein degradation | |
Fbxw7 | Ubiquitination | Protein degradation | |
Set7 | K494-me | Cytoplasmic retention | |
CBP/p300 | K494-ac; K497-ac | Altered nuclear activity | |
PML | K97-sumo, K280-sumoh | Stabilizes YAP1 by sumoylation and enhances p73-dependent transcription | |
TAZ | LATS1/2 | S66-p, S117-p | Cytoplasmic retention |
S89-p | The binding of 14-3-3 | ||
S311-p | Facilitates the binding of CK1δ/ε, leading to further serine phosphorylations | ||
GSK3-beta | S58-p, S62-p | Degradation | |
NEK1/CK1ε/δ | S314-p | Degradation/β-TrCP recruitment | |
c-Abl | Y321-p | Altered nuclear activity | |
PP1 | S89-dep,S311-dep | Promotes TAZ nuclear translocation, and stabilizes TAZ by disrupting the binding to the SCF E3 ubiquitin ligase |