Target | Compounds | Function |
---|---|---|
ILK | QLT0267 | Activation of the Hippo pathway components MST1 and LATS1 with concomitant inactivation of YAP/TAZ and TEAD-mediated transcription |
Itch | Clomipramine | A clinically useful antidepressant drug. The effects in cancer cells treated with clomipramine included reduction of cell growth, and synergism with gemcitabine or mitomycin in killing cancer cells through autophagy blockade |
Nedd4 | Heclin | Bicyclic peptides, kills HEK293 cells growing in culture |
SIAH1/2 | BI-107F7 | Peptide-mimetics, efficient covalent inhibitors of Siah and antagonize Siah-dependent regulation of Erk and Hif signaling in cell |
BI-107F9 |